Managing railway safety in high-density areas requires running several organizational processes. These processes follow the evolution of regulations, technologies and organizational practices, which need to set up a global safety excellence initiative that ensures coherence among them and facilitates the tasks of managers and staff. SNCF launched PRISME in February 2015 to structure and develop coherence among these processes. PRISME gathers six main goals: proactive behaviour, risk-driven management, cooperation between activities, simplification of procedures, individual commitment to safety and investment in innovative equipment. In this paper, the organization set up to achieve the second goal: risk-driven management is presented